What is the one rune you have a hard time with?

AA, Boa / anything with stupid defense, knohkan Guide <--- Hate this one!!!

 

I played a friendly game against Zeya and he deployed Vex first turn and I instantly surrendered and asked for a rematch after switching to my main deck lol. And if I could get an actual real life card of Boa I would put it in my shredder and cry out of joy.

 

i know is only my issue but , every fking rune in a good player hand uff