I do not really understand: "interactions" play a deck with 6 or more champions with an ability that has relic? but I thought it was ability amplify frost?
You get 4 Heroic Quests. They will ask you to either INCLUDE X type of runes in your deck or PLAY them. They usually ask you to play units with a specific ability. If you post a screenshot of your quests I can try to give you a better idea of what you need to do.